Chronic myeloid Leukemia Leukemia is a type of cancer that affects the make animal and trick up marrow. Chronic myeloid leukemia (CML) is a myeloproliferative dis wholeege characterized hematologically by marked leukocytosis, basophilia, and eosinophilia, the leukocytosis is due primarily to an sum up in be on and immature neutrophils. CML is a clonal disorder associated in well-nigh all cases with a t(9;22)chromosome commonly manifest as the Philadelphia (Ph) chromosome, molecular evidence of the translocation of the abl oncogene from chromosome 9 to the breakpoint cluster region (bcr) of chromosome 22. (Rajendra Persad 2001) courting study of CML/ Patient chronicle: The patient is a 58 year old lily-white female who was diagnosed with Chronic Myeloid Leukemia (CML) positive for the Philadelphia chromosome by sheer cytogenetics, seven months previously. A buy up b nonpareil marrow performed five months after diagnosis, to measure resolution to interferon and h ydroxyurea manipulation findings consistent with CML, with persistence of the Ph chromosome and less than 1% blasts. She is straightway being evaluated prior to bone marrow transplant. (Rajendra Persad 2001) PB find: Hb11.1 g/dl(normal 11.7 -15.7) Plt246 x10E+9/L(normal 150 -450) WBC84.2 x10E+9/L(normal 4.5 -11.0) Blasts(1%) 0.84(normal < 0.02) Promyelocyte (1%) 0.84 Promyelocyte(1%) 0.
84 Myelocytes(5%) 4.21 Metamyelocytes(9%) 7.58 Bands(23%) 19.37(normal 0.1 -0.8) Polys(43%) 36.22(normal 2.0 - 6.8) Basophils (2%) 1.68 (normal < 0.2) A bone marrow aspirate, with the following differential: Blasts19% (normal 0.0 -2.0) Basophils5.3% (normal 0.0! - 0.2) M:E ratio 6.1% (normal 1.5 - 3.3) Ph chromosome positive The incidence of CML is 1-1.5/ 100 000 population, constituting 15-20 % of all leukemias, devising it the commonest of the chronic myeloproliferative disorders. With a median age of 53years, intimately one third of patients are older than 60 years. CML is rare in childhood, accounting for...
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